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KMID : 0378019890320010143
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New Medical Journal
1989 Volume.32 No. 1 p.143 ~ p.146
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Effect on protein and lipid oxidation by topically applied cosmetic(VO^(®)) in UVA irradiated white Swiss mouse skin
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Abstract
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The effect of cosmetic (VO: Vegog Saeng®) on aging process of the skin was studied in, white Swiss mouse. Mixed-function oxidation (MFO) systems are recognized to be implicated in peroxidation of proteins and lipids, which are considered biochemical alteration of aging process. The oxidation of the skin proteins was assessed by the quantity of protein carbonyl derivatives as determined by 2,4-dinitrophenylhydrazine (DNPH) reaction. The oxidation of the skin lipids to lipid peroxides was determined by thiobrabituric acid (TBA) reaction.
The level of protein carbonyl derivatives in the cosmetic applied group was 0.11+0.034, which as significantly lower than that of the control group (0.14±0.026) (p<0.05). The lipid peroxides level of he cosmetic applied group, expressed as relative fluorescence/mg protein, was 12.4±2.15, which was significantly lower than that of the control group (19.3±3.77) (p<0.01).
It is suggested from these results that long-term application of the cosmetic (VO®) can preventor decelerate the aging process of the skin.
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